Panacur C Fenbendazole Cancer Summary

Researched and written by Keith Bishop, Clinical Nutritionist, B.Sc. Pharmacy 03/31/2021.

Many customers and clients are asking me about Panacur C dog heartworm treatment for cancer so I’m providing a summary of Joe Tippens’ protocol and a summary of the medical research on cancer and fenbendazole.

Joe Tippens has been taking fenbendazole as part of his cancer treatment for several years and has a blog discussing his cancer journey. The summary of his protocol follows:

  • Fenbendazole as Panacur or Safe-guard canine dewormer. 1 Gram per day for 7 consecutive days per week. This is equal to 222 mg of fenbendazole. It appears to be better absorbed with food or meals. Monitor blood liver tests and decrease the dose if needed. If in remission decrease the dose to 1 gram per day for 3 consecutive days per week.
  • Theracurmin HP: 1 capsule by mouth twice daily
  • Cantek (American Wholesale Hemp) CBD Emerald 2,500mg: 1 dropperful under the tongue 1-2 times daily.
  • Vitamin E has been removed from the protocol due to potential prolonged bleeding issues.

Fenbendazole has not been approved for human use and is not approved for cancer treatment. At the time I researched and wrote this article there were not any human cancer studies or trials with fenbendazole. Thus far research has been limited to laboratory human cancer cell and human cancer cells or tumors transplanted into animal studies. The research is lacking partially because this drug is only approved for animal use in the U.S. and it is a generic drug and therefore drug companies can’t recoup their research investment from expensive human trials. I doubt this drug will ever be developed for human use. I do expect similar medications in this drug class, Benzimidazole to be developed and approved for human use in the next 10 years.

Keith Bishop, CN, Bs Pharmacy

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Here are a few summaries from fenbendazole medical cancer research:

Benzimidazole anti-parasite drugs (of which fenbendazole is a member of) are known to exert anticancer activities, such as (sorry for the following medical terms) the disruption of microtubule polymerization (decreasing the beginning of cell division leading to multiple cells), the induction of apoptosis (helping with normal cell death), cell cycle (G2/M) arrest (decreasing cell division leading to multiple copies of cells), anti-angiogenesis (decreases new blood vessel growth to cancer tumors), and blockage of glucose transport (decreases energy to cancer cells). These antitumorigenic effects even extend to cancer cells resistant to approved therapies (chemo and radiation) and when in combination with conventional therapeutics, enhance anticancer efficacy and hold promise as adjuvants (enhancers).[1]

In a cancer cell laboratory study fenbendazole was effective in killing KRAS-activated human non-small cell lung cancer (NSCLC) cells.[2]

In another cancer cell laboratory study treatment of human NSCLC cells with fenbendazole induced endoplasmic reticulum stress, reactive oxygen species production, decreased mitochondrial membrane potential, and cytochrome c release that eventually led to cancer cell death.[3]

Human lymphoma tumors were implanted into mice. The group of mice that received a combination of vitamins and fenbendazole exhibited significant inhibition of tumor growth.[4]

Prostate cancer cells were implanted into mice. A specialized highly absorbable form of fenbendazole significantly prolonged survival in mice bearing metastases.[5] A group or researchers are trying to make a patentable drug version.

References Sources Include: Joe Tippens’ Blog, accessed 03/19/2021

[1] Son DS, Lee ES, Adunyah SE. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw. 2020 Aug 4;20(4):e29.

[2] Shimomura I, Yokoi A, et al. Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer. Cancer Lett. 2019 Jun 1;451:11-22.

[3] Dogra N, Mukhopadhyay T. Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication. J Biol Chem. 2012 Aug 31;287(36):30625-40.

[4] Gao P, Dang CV, Watson J. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. J Am Assoc Lab Anim Sci. 2008 Nov;47(6):37-40. PMID: 19049251; PMCID: PMC2687140.

[5] Chung I, Zhou K, et al. Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer. Front Oncol. 2021 Mar 2;10:594141.

These statements have not been evaluated by the Food and Drug Administration. These products is not intended to diagnose, treat, cure, or prevent any disease. This information is provided for information purposes. You should contact your healthcare provider before making changes in your health program or if you have questions about how you are feeling.