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This is our most comprehensive hormone assessment: 23 hormones and hormone-related markers from a single morning saliva sample, analyzed by LC-MS/MS at ZRT Laboratory. Rather than measuring a handful of hormones, it maps entire hormone pathways.
| Laboratory | ZRT Laboratory |
| Profile | Saliva Steroid LC-MS Profile 23 |
| Markers | 23 |
| Collection | One morning saliva sample, at home |
| Method | LC-MS/MS |
| Included | One follow-up consultation with a Flourish nutrition professional |
| Not suitable for | Sublingual hormone users. See below. |
This is ZRT's Saliva Steroid LC-MS Profile 23: 18 endogenous steroid hormones, plus melatonin, plus the synthetic estrogen ethinyl estradiol found in most oral contraceptive formulations, plus three steroid synthesis inhibitors.
Naming the underlying profile matters, because it tells you exactly what you are paying for.
Training performance is influenced by far more than testosterone alone. Your ability to build muscle, recover from hard training, hold energy, regulate body composition, manage stress and sleep depends on how several hormone systems interact.
Most hormone tests answer one question: how much hormone is present. Testing both the upstream precursors and the downstream metabolites of the active hormones helps show which steroid synthesis enzymes are underactive, overactive, or blocked, whether by natural or pharmaceutical inhibitors. That is the difference between a level and a pathway.
Estrogen pathway. Estradiol (E2), estrone (E1), estriol (E3), ethinyl estradiol (EE).
Progesterone pathway. Pregnenolone sulfate (PregS), progesterone (Pg), allopregnanolone (AlloP), 17-OH progesterone (17OHPg).
Androgen pathway. Androstenedione, testosterone, dihydrotestosterone (DHT), DHEA, DHEA-S, 7-keto DHEA.
Glucocorticoid pathway. 11-deoxycortisol (11DC), cortisol, cortisone.
Mineralocorticoid pathway. Corticosterone, aldosterone.
Sleep marker. Melatonin.
Steroid synthesis inhibitors. Anastrozole, finasteride, letrozole. These are aromatase and 5-alpha-reductase inhibitors used in hormone optimization. Because they change how hormones are metabolized, knowing whether they are present changes how the rest of the report reads.
Saliva measures the bioavailable, unbound fraction of hormones, the portion actually available to tissues. ZRT describes this as relating more closely to symptoms of excess or deficiency than a total blood level does.
LC-MS/MS is the method ZRT uses for this profile. It measures 23 markers from one sample, including several that the standard five-hormone immunoassay panel does not report.
ZRT states that saliva testing is not appropriate for sublingual hormone users, because the hormone contaminates the sample directly, and that blood spot testing is the preferred option for these patients.
Flourish compounds sublingual hormones, so we would rather tell you this before you order than after your result comes back unreadable. Call 405-751-3333 and we will route you to the right method.
A wellness and monitoring tool, not a diagnostic test, and not a replacement for evaluation by your physician. It does not diagnose any condition. It is also not a doping screen: it measures endogenous steroid hormones plus one synthetic estrogen and three named synthesis inhibitors.
What hormones should an athlete test?
Testosterone alone rarely explains performance. This panel maps the androgen pathway including DHT, DHEA, DHEA-S and 7-keto DHEA, the estrogen pathway, the progesterone pathway, cortisol and cortisone, the mineralocorticoids aldosterone and corticosterone, and melatonin.
What is a 23-marker hormone panel?
ZRT's Saliva Steroid LC-MS Profile 23: 18 endogenous steroid hormones plus melatonin, ethinyl estradiol, and three steroid synthesis inhibitors.
Why does the panel test for anastrozole, finasteride and letrozole?
These are aromatase and 5-alpha-reductase inhibitors used in hormone optimization. Because they change how hormones are metabolized, knowing whether they are present changes how the rest of the report reads.
How is this different from a testosterone test?
A testosterone test gives one number. This shows the precursors testosterone is built from and the metabolites it becomes, which is what indicates where in the pathway something is limiting.
Can women take this panel?
Yes. It measures the full steroid cascade, and estrogen, progesterone and androgen pathways all matter for training adaptation in both sexes.
Does it test for performance-enhancing drugs?
No. It is not a doping screen. It measures endogenous steroid hormones plus three specific synthesis inhibitors and one synthetic estrogen.
How is the sample collected?
One morning saliva sample at home, with prepaid shipping to ZRT Laboratory.
Can I use this if I am on hormone therapy?
It depends on the form. If you use a sublingual preparation, saliva is not the right method and ZRT recommends blood spot instead. Call 405-751-3333 before ordering.
How long do results take?
About two weeks after the laboratory receives your sample.
Contact the Flourish team or call 405-751-3333 before ordering. There are smaller panels that answer narrower questions for a lot less, and we would rather point you at one of those than sell you this.
Based on testing performed by ZRT Laboratory.
The Food and Drug Administration has not evaluated these statements. Flourish-supported products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.
