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5 Clinically Studied Bacillus Spore Strains
Reconditions & Restores Gut Health
Supports Healthy Gut Barrier & Immunity
Fast Delivery
Easy Returns
Manage Subscriptions Anytime
Many probiotics never make it past your stomach acid. MegaSporeBiotic is different: a blend of five hardy Bacillus spores that stay dormant through digestion and activate in the intestine, where they've been clinically shown to support gut-barrier function and immunity — reconditioning the gut rather than just reseeding it.
| Brand | Microbiome Labs |
| What it is | 5-strain Bacillus spore probiotic |
| Form | Capsules |
| Notable | Spores survive stomach acid; antioxidant-producing |
| Best for | Gut-barrier function & immunity |
| Pairs well with | MegaPrebiotic, MegaMucosa, Extra Strength Probiotic |
If you are immunocompromised or seriously ill, check with your provider before starting any live probiotic.
Ordinary probiotics are living cells that can be destroyed by stomach acid before they reach the intestine. Bacillus spores have a protective, dormant phase — they pass through the stomach intact, then activate in the large intestine and begin working. This is why spore probiotics are described as “reconditioning” the gut, and why MegaSporeBiotic has become a practitioner favorite for gut-barrier and immune support.
Take as directed on the label, or as directed by your healthcare practitioner (many start with a lower dose and build up).
Flourish is a compounding pharmacy with an on-staff pharmacist and nutrition team, so your questions about gut-barrier and immune support reach people who do this every day — not a warehouse. Explore Probiotics, Gut Health, or pair it with MegaPrebiotic, MegaMucosa, Extra Strength Probiotic.
What is MegaSporeBiotic?
A five-strain Bacillus spore probiotic designed to survive stomach acid and support gut-barrier function and immunity.
What does “spore-based” mean?
The probiotics are in a dormant spore form that survives digestion and activates in the intestine, unlike many live-cell probiotics.
Why is survival important?
A probiotic only helps if it reaches the gut alive; spores are built to make that journey.
Does it need refrigeration?
Spore-based probiotics are shelf-stable — confirm storage on the label.
How do I start it?
Many people start with a lower dose and increase gradually; follow the label or your practitioner's guidance.
Can I take it with a prebiotic?
Yes — it's often paired with a prebiotic and mucosal support as part of a gut protocol.
Who makes it?
Microbiome Labs.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.
