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Vitamin B12 works along with folate in many body processes, including increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function.
Supports Energy, Mood & Cognitive Function
Promotes Healthy Nerve & Myelin Health
Bioactive B12 & Folate Methylation Formula
Fast Delivery
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If you've been taking a B12 and not feeling much, the form may be why. Most B12 is cyanocobalamin, which your body has to convert before it can use it. Methyl B12 skips that step: it provides 5,000 mcg of methylcobalamin — the active, tissue-ready form — plus 1,000 mcg of methylfolate (Quatrefolic 5-MTHF), to support healthy B12 status, energy, nerve function, and healthy homocysteine.
| Brand | Ortho Molecular |
| Actives | Methylcobalamin 5,000 mcg + methylfolate 1,000 mcg (5-MTHF) |
| Form | Tablets |
| Best for | Energy, nerves, mood, methylation |
| Notable | Active forms — no conversion needed |
| Pairs well with | Methyl B-Complex, B Active, 5-MTHF |
If you have a diagnosed B12 deficiency or take medication that affects B12, work with your provider on dosing and monitoring.
To use ordinary B12 (cyanocobalamin), your liver first removes a cyanide group and adds a methyl group to make methylcobalamin — the active form. Methyl B12 provides that active form directly, so it's ready for your tissues without the conversion step, and it's paired with methylfolate (5-MTHF) because B12 and folate work together in methylation, red blood cell production, and nerve health.
Take one tablet daily, or as directed by your healthcare practitioner.
Flourish is a compounding pharmacy with an on-staff pharmacist and nutrition team, so your questions about B12, energy, and methylation reach people who do this every day — not a warehouse. Explore Vitamins & Minerals, Energy, or pair it with Methyl B-Complex, B Active Complex, 5-MTHF.
What is methylated B12?
Methylcobalamin — the active, body-ready form of vitamin B12 that doesn't require the conversion step ordinary cyanocobalamin does.
Is Methyl B12 the same as methylated B12 or methylcobalamin?
Methylcobalamin is a methylated form of vitamin B12. Ortho Molecular's Methyl B12 contains methylcobalamin along with methylfolate (5-MTHF).
How is it different from regular B12?
Regular B12 (cyanocobalamin) must be converted by the body; methylcobalamin is already in the usable form.
How much B12 is in each tablet?
5,000 mcg of methylcobalamin, plus 1,000 mcg of methylfolate (5-MTHF).
Does it contain folic acid?
No. It uses methylfolate (5-MTHF), the active form of folate, rather than folic acid.
Can too much B12 be harmful?
B12 is water-soluble and generally well tolerated, but if you have elevated B12 on labs, review it with your provider.
When should I take it?
Once daily; many take B vitamins earlier in the day.
Does it help energy?
B12 supports normal energy metabolism and red blood cell formation.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.
