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Designed to provide comprehensive support for seasonal challenges caused by common environmental allergens.
Quercetin, Bromelain & Nettles Blend
Supports Healthy Seasonal Immune Response
Comprehensive Histamine & Allergy Support

Natural D-Hist is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals formulated by Ortho Molecular to provide comprehensive support through seasonal challenges. The formula combines quercetin, bromelain, stinging nettles leaf and N-acetyl cysteine, and is designed to promote healthy nasal and sinus passages.
Natural D-Hist is drug-free. It contains no diphenhydramine or other sedating antihistamine medications — just quercetin, bromelain, stinging nettles and NAC — so many people reach for it as a daily option through allergy season.
Quercetin is a flavonoid that supports normal histamine balance. Bromelain is a proteolytic enzyme derived from pineapple that supports the absorption of quercetin and normal mucosal health. Stinging nettles leaf has a long history of traditional use for seasonal support. N-acetyl cysteine (NAC) supports normal mucus viscosity and healthy respiratory function.
Is D-Hist the same as Natural D-Hist?
Yes. The product is Ortho Molecular's Natural D-Hist, and it is commonly written as D-Hist, D Hist or DHist. All refer to the same formula.
How is Natural D-Hist taken?
Follow the serving directions on the label, or the guidance from your prescriber. Ortho Molecular publishes both a short loading schedule for the first several days and a lower ongoing serving; if you are not sure which applies to you, call 405-751-3333 and ask to speak with a pharmacist.
What is the difference between Natural D-Hist and Natural D-Hist Jr?
Same formula family. The Jr version is a chewable made for children at a smaller serving size.
Do I need a prescription?
No. Natural D-Hist is a dietary supplement. It is available in store at 14720 N Pennsylvania Ave in Oklahoma City, and we ship supplements nationwide.
Is Natural D-Hist non-drowsy?
Natural D-Hist is drug-free and contains no diphenhydramine or other sedating antihistamine drugs found in many over-the-counter allergy products. It is formulated from quercetin, bromelain, stinging nettles and NAC. Individual response varies — if you have questions about how it fits your routine, call 405-751-3333 and ask for a pharmacist.
How does Natural D-Hist compare with over-the-counter antihistamines?
They take different approaches. Over-the-counter antihistamines are drugs that block the H1 histamine receptor. Natural D-Hist is a dietary supplement that supplies botanicals and nutrients — quercetin, bromelain, nettles and NAC — that support the body's own healthy histamine balance and normal mucus viscosity. Some people prefer a drug-free daily option; others use it alongside other measures. Your pharmacist or physician can help you decide what fits your situation.
Can I take Natural D-Hist with my other medications or supplements?
Check with your health care provider before taking Natural D-Hist alongside other prescription medications. Our pharmacists are also glad to review your full list — call 405-751-3333.
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These statements have not been evaluated by the Food and Drug Administration. Flourish supported products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.