Advanced Saliva Hormone & Cortisol Panel - ZRT Labs

Comprehensive Hormone Balance & Adrenal Stress Testing

The Advanced Saliva Hormone & Cortisol Panel is a comprehensive at-home saliva test designed to evaluate both sex hormone balance and daily cortisol rhythm in a single collection kit. This panel measures five key biomarkers associated with energy, mood, stress resilience, metabolism, sleep quality, libido, and healthy aging.

Using highly sensitive LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) technology, this test provides accurate assessment of:

• Estradiol (E2)
• Progesterone
• Testosterone
• DHEA-Sulfate (DHEA-S)
• Cortisol (4 daily measurements)

By combining hormone analysis with a four-point cortisol rhythm assessment, this test offers a detailed view of endocrine function and stress response patterns throughout the day.

What This Test Measures

Sex Hormones

Estradiol (E2)
A primary estrogen involved in reproductive health, mood regulation, cognitive function, bone health, and cardiovascular wellness.

Progesterone
Supports menstrual cycle balance, sleep quality, mood stability, and healthy hormone regulation.

Testosterone
Important for energy, muscle maintenance, libido, motivation, mental clarity, and overall vitality in both men and women.

DHEA-Sulfate (DHEA-S)
An adrenal hormone that serves as a precursor to other hormones and plays a role in resilience, healthy aging, and stress adaptation.

Adrenal Stress Response

4-Point Cortisol Rhythm
Measures cortisol at four separate times during the day to evaluate your natural cortisol curve. A healthy cortisol rhythm helps regulate:

• Energy production
• Sleep-wake cycles
• Stress response
• Immune function
• Metabolism
• Cognitive performance

Identifying abnormal cortisol patterns can provide insight into chronic stress, burnout, fatigue, sleep disruption, and HPA-axis dysfunction.

Why Saliva Testing?

Saliva testing measures the bioavailable fraction of hormones—the portion that is freely available to interact with tissues and cells throughout the body. This makes saliva testing particularly useful for evaluating hormone balance and monitoring hormone-related symptoms.

Unlike blood testing, saliva collection is non-invasive, convenient, and can be completed from home without a laboratory visit.

Advanced LC-MS/MS Technology

This panel utilizes Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), one of the most advanced laboratory methods available for hormone testing.

Benefits include:

• High analytical accuracy
• Improved sensitivity for low hormone levels
• Enhanced estradiol measurement precision
• Reliable results for men, women, and postmenopausal individuals
• Reduced interference compared with traditional immunoassay methods

Who May Benefit From This Test?

This comprehensive hormone and cortisol panel may be helpful for individuals experiencing:

• Chronic fatigue or low energy
• Stress and burnout symptoms
• Poor stress resilience
• Sleep disturbances
• Mood swings or irritability
• Anxiety or emotional fluctuations
• Low libido
• Weight management challenges
• Perimenopause or menopause symptoms
• Andropause symptoms
• PMS symptoms
• Hormone imbalance concerns
• Monitoring bioidentical hormone replacement therapy (BHRT)
• Adrenal function concerns
• HPA-axis dysfunction

What You'll Receive

• Easy-to-use at-home saliva collection kit
• Collection instructions
• Laboratory analysis of five hormone markers
• Four-point cortisol rhythm assessment
• Comprehensive results report
• Practitioner-ready data for personalized wellness planning

Biomarkers Included

Frequently Searched Terms

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Test Method

Saliva Collection • LC-MS/MS Analysis

Laboratory Panel

ZRT S-141 Comprehensive Saliva Hormone & Cortisol Assessment

Personalized Results Review with a Nutritionist Included

Your purchase includes a one-on-one follow-up consultation with a licensed nutrition professional to help you better understand your results and next steps.

After your laboratory results are available, you'll meet with a member of our clinical nutrition team to review your hormone and cortisol findings in detail. During this consultation, you'll receive personalized guidance based on your results, symptoms, health goals, and lifestyle factors.

What to Expect During Your Consultation

Your nutritionist will help you:

• Understand each biomarker included in your report
• Review hormone balance patterns and cortisol rhythm findings
• Identify potential contributors to symptoms such as fatigue, stress, poor sleep, low energy, mood changes, and weight concerns
• Discuss nutrition and lifestyle factors that may impact hormone health
• Review supplement recommendations when appropriate
• Answer questions about your laboratory results
• Develop actionable next steps to support your wellness goals

Why This Matters

Laboratory testing provides valuable data, but understanding how those results relate to your symptoms and overall health is equally important. Our included results review helps bridge the gap between testing and action, giving you clear, personalized guidance rather than simply receiving a laboratory report.

Included at No Additional Cost

Every Advanced Saliva Hormone & Cortisol Panel purchase includes:

• Comprehensive laboratory analysis
• Detailed results report
• Professional review of your findings
• One follow-up consultation with a nutritionist
• Personalized wellness recommendations based on your results

Our goal is to help you move beyond numbers on a page and gain meaningful insights that support long-term hormone balance, stress resilience, energy, and overall well-being.